Pharmacology of Asthma


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J Pharmacol Exp Ther.

Role of phosphoinositide metabolism in human bronchial smooth muscle contraction and in functional antagonism by beta-adrenoceptor agonists. Am Rev Respir Dis. In vivo functional antagonism between isoproterenol and bronchoconstrictants in the dog. J Appl Physiol.

Potentiation of beta-adrenoceptor function in bovine tracheal smooth muscle by inhibition of protein kinase C. Eur J Pharmacol. Protein kinase C potentiates homologous desensitization of the beta2-adrenoceptor in bovine tracheal smooth muscle.

The Pathophysiology of Asthma

Muscarinic blockade of beta-adrenoceptor-stimulated adenylyl cyclase: the role of stimulatory and inhibitory guanine-nucleotide binding regulatory proteins Gs and Gi. G protein-coupled receptors: heterologous regulation of homologous desensitization and its implications. Effect of tiotropium bromide on airway remodeling in a chronic asthma model. Ann Allergy Asthma Immunol.

Medications for Asthma

Efficacy of anticholinergic drugs in asthma. Gross NJ. Anticholinergic agents in asthma and COPD. Anticholinergic agents for chronic asthma in adults. Cochrane Database Syst Rev. Fryer AD, Maclagan J.

Ipratropium bromide potentiates bronchoconstriction induced by vagal nerve stimulation in the guinea-pig. Pera T, Penn RB.

Passar bra ihop

Crosstalk between betaadrenoceptor and muscarinic acetylcholine receptors in the airway. Curr Opin Pharmacol. Mol Med Rep. Muscarinic receptor antagonists, from folklore to pharmacology; finding drugs that actually work in asthma and COPD. Atropine methonitrate and isoprenaline in bronchial asthma.

Rodrigo GJ, Rodrigo C. The role of anticholinergics in acute asthma treatment: an evidence-based evaluation. Ba BR, a novel long-acting anticholinergic bronchodilator.

COPD, Asthma, and Pharmacology | RT

Tiotropium bromide Ba BR , a novel long-acting muscarinic antagonist for the treatment of obstructive airways disease. Tiotropium Bromide. Open Chemistry database. Barnes PJ. The pharmacological properties of tiotropium. Autoradiographic visualization of muscarinic receptor subtypes in human and guinea pig lung.


  1. Review ARTICLE.
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  4. Drugs Used in Asthma | Basic & Clinical Pharmacology, 13e | AccessMedicine | McGraw-Hill Medical!

Tiotropium bromide. Tiotropium Spiriva : mechanistical considerations and clinical profile in obstructive lung disease. Prolonged effect of tiotropium bromide on methacholine-induced bronchoconstriction in asthma. Early protective effects of tiotropium bromide in patients with airways hyperresponsiveness. Eur Rev Med Pharmacol Sci.

Expert Opin Pharmacother. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. Inflammation and structural changes in the airways of patients with atopic and nonatopic asthma.

Asthma - Clinical Presentation

BHR Group. Tiotropium sustains the anti-inflammatory action of olodaterol via the cyclic AMP pathway. Holgate ST. The sentinel role of the airway epithelium in asthma pathogenesis. Immunol Rev. Why use long acting bronchodilators in chronic obstructive lung diseases? Eur J Intern Med. Muscarinic M3 receptor stimulation increases cigarette smoke-induced IL-8 secretion by human airway smooth muscle cells.

Bronchodilators modulate inflammation in chronic obstructive pulmonary disease subjects. Pharmacol Res. Tiotropium suppresses acetylcholine-induced release of chemotactic mediators in vitro. Wollin L, Pieper MP. Tiotropium bromide exerts anti-inflammatory activity in a cigarette smoke mouse model of COPD. Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD.

Inhibitory effects of tiotropium on rhinovirus infection in human airway epithelial cells. Inhibition of allergen-induced airway remodelling by tiotropium and budesonide: a comparison. Combination therapy of tiotropium and ciclesonide attenuates airway inflammation and remodeling in a guinea pig model of chronic asthma. Bronchoprotection by olodaterol is synergistically enhanced by tiotropium in a guinea pig model of allergic asthma.

Smoke, choline acetyltransferase, muscarinic receptors, and fibroblast proliferation in chronic obstructive pulmonary disease. Acetylcholine-induced proliferation of fibroblasts and myofibroblasts in vitro is inhibited by tiotropium bromide. Suppressive activity of tiotropium bromide on matrix metalloproteinase production from lung fibroblasts in vitro. Effect of tiotropium bromide on airway inflammation and remodelling in a mouse model of asthma. Clin Exp Allergy. Chronic cough and sputum production are associated with worse clinical outcomes in stable asthma. Rogers DF.

Motor control of airway goblet cells and glands. Respir Physiol. Inhibition of neutrophil elastase-induced goblet cell metaplasia by tiotropium in mice. Chronic persistent cough: use of ipratropium bromide in undiagnosed cases following upper respiratory tract infection. Effect of bronchodilators on the cough response to inhaled citric acid in normal and asthmatic subjects. Antitussive properties of inhaled bronchodilators on induced cough.

Tiotropium reduction of lung inflammation in a model of chronic gastro-oesophageal reflux. Pharmacological studies of allergic cough in the guinea pig. Pharmacological and non-pharmacological interventions for cough in adults with respiratory and non-respiratory diseases: a systematic review of the literature.

Effect of tiotropium on cough reflex sensitivity in acute viral cough. Tiotropium modulates transient receptor potential V1 TRPV1 in airway sensory nerves: a beneficial off-target effect?


  • COPD, Asthma, and Pharmacology?
  • Learning Objectives.
  • Clinical Case.
  • Downregulation of the cough reflex by aclidinium and tiotropium in awake and anesthetized rabbits. A randomized dose-ranging study of tiotropium respimat in children with symptomatic asthma despite inhaled corticosteroids.

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    Pharmacology of Asthma Pharmacology of Asthma
    Pharmacology of Asthma Pharmacology of Asthma
    Pharmacology of Asthma Pharmacology of Asthma
    Pharmacology of Asthma Pharmacology of Asthma
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